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Science Abstracts
A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration
December 2008

Authors : Shin Wakatsuki1 , Jun-ichi Suzuki1,2 , Masahito Ogawa1 , Mayumi Masumura1 , Susumu Muto3 , Tomoko Shimizu4 , Kiyoshi Takayama4 , Akiko Itai3 , Mitsuaki Isobe1

Affliation :

1Tokyo Medical and Dental University, Department of Cardiovascular Medicine, 1-5-45 Yushima, Bunkyo, Tokyo, Japan

†2University of Tokyo, Graduate School of Medicine, Department of Advanced Clinical Science and Therapeutics, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan ; ; junichisuzuki-circ@umin.ac.jp

3Institute of Medicinal Molecular Design, Inc., 5-24-5 Hongo, Bunkyo, Tokyo, Japan

4NB Health Laboratory, A1-659, 3-12-18, Kamiaoki, Kawaguchi, Saitama, Japan

DOI : 10.1517/14728220802551140

Published in : Expert Opin. Ther. Targets Volume 12 Issue 12 2008 pages 1469 1476

Subject: Original Research

Keywords: brain natriuretic peptide , fibrosis , heart failure , inflammation , matrix metalloproteases , myocardial ischemia , remodeling

 
Abstract

Objective: Amplification of inflammatory...

 

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